The story begins after the death of Boss Suchart, an elephant camp boss powerful. The assassins were deliberately fabricated false evidence to blame Kham (Tony Jaa) when he accidentally appeared at the scene of the crime. Kham has to escape before the police arrest. Meanwhile,Ping Ping and Xu Xinh - two daughter twin is seeking revenge for the unlucky uncle- Boss Suchart. Fortunately, Kham met Sergeant Mark, an Interpol agent was sent to Thailand to carry out a secret mission. Before the pursuit of many different factions, Kham also on the retrieval Khons beloved elephant which disappeared along with the death of Suchart Boss. In the difficult journey, Kham is also involved in competition arena in the underworld LC (RZA) boss organize. Those his boxers including pique Twenty female assassin and foxy boxer named No. 2. The two assassins are asked to defeat and capture Kham alive..