A Las Vegas casino owner desperate for a new "event" to wager on invents a human race for cash. The competitors are Owen who ends up driving a bus full of Lucille Ball imitators, a foreigner who hitches a ride in an organ donor vehicle, and a recently reunited mother and daughter who anger a "squirrel lady", much to their regret. There are also two con artist brothers, the upright Nick, who gets a lift from cute but psychotic pilot Tracy, and the eccentric Pear family..